Pyr3

Name: Pyr3
Brand: Tocris Bioscience
SKU: 3751

Tocris Bioscience, part of Bio-Techne | Catalog # 3751

(1)

Citations (32)

COA / SDS

Selective TRPC3 inhibitor

Key Product Details

Chemical Name:	1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
Purity:	≥98%
Molecular Weight:	456.63 kDa

View Full Technical Details for Pyr3

Technical Data
Citations / Reviews (1)

Biological Activity for Pyr3

Pyr3 is a selective antagonist of the canonical transient receptor potential channel 3 (TRPC3). Inhibits TRPC3-mediated Ca²⁺ influx (IC₅₀ = 0.7 μM) and suppresses activation of nuclear factor of activated T cells (NFAT). Inhibits hypertrophic responses in cardiomyocytes.

Technical Data for Pyr3

M. Wt	456.63 kDa
Formula	C₁₆H₁₁Cl₃F₃N₃O₃
Storage	Store at -20°C
Purity	≥98%
CAS Number	1160514-60-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pyr3

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Pyr3

References are publications that support the biological activity of the product.

Kiyonaka et al. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc.Natl.Acad.Sci., 2009;106:5400