R 7050

Tocris Bioscience, part of Bio-Techne | Catalog # 5432

(1)

Citations (14)

COA / SDS

Inhibitor of TNF-α receptor 1 signaling

Key Product Details

Description:	Inhibitor of TNF-α receptor 1 signaling
Chemical Name:	8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
Purity:	≥98% (HPLC)
Molecular Weight:	380.77

View Full Technical Details for R 7050

Technical Data
Citations / Reviews (1)

Biological Activity for R 7050

R 7050 is an inhibitor of TNF-α receptor 1 (TNFR1) signaling; blocks TNFR1 association with TRADD and RIP1. Inhibits TNF-α-induced NF-κB and MAPK signaling pathway activation. Attenuates intracerebral hemorrhage-induced neurovascular injury in mice.

Technical Data for R 7050

M. Wt	380.77
Formula	C₁₆H₈ClF₃N₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	303997-35-5
PubChem ID	1486608
InChi Key	SUUMKHOVGVYGOP-UHFFFAOYSA-N
Smiles	ClC1=CC=C(N=C(SC4=CC=CC=C4)C2=NN=C(C(F)(F)F)N23)C3=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for R 7050

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.62	20

Preparing Stock Solutions for R 7050

The following data is based on the product molecular weight 380.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.13 mL	65.66 mL	131.31 mL
1 mM	2.63 mL	13.13 mL	26.26 mL
2 mM	1.31 mL	6.57 mL	13.13 mL
10 mM	0.26 mL	1.31 mL	2.63 mL

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References for R 7050

References are publications that support the biological activity of the product.

King TNF-α receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice. Neurosci.Lett. 2013 PMID: 23499961
Gururaja A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1. Chem.Biol. 2007 PMID: 17961823