rac BHFF

Name: rac BHFF
Brand: Tocris Bioscience
SKU: 3313

Tocris Bioscience, part of Bio-Techne | Catalog # 3313

Citations (5)

COA / SDS

Potent and selective postitive allosteric modulator of GABAB receptors

Key Product Details

Description:	Potent and selective postitive allosteric modulator of GABA_B receptors
Chemical Name:	5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranone
Purity:	≥98% (HPLC)
Molecular Weight:	330.34

View Full Technical Details for rac BHFF

Technical Data
Citations

Biological Activity for rac BHFF

rac BHFF is a potent and selective GABA_B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). Exhibits anxiolytic activity in vivo and is orally active.

Compound Libraries for rac BHFF

rac BHFF is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for rac BHFF

M. Wt	330.34
Formula	C₁₇H₂₁F₃O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	123557-91-5
PubChem ID	4332683
InChi Key	RVNOANDLZIIFHB-UHFFFAOYSA-N
Smiles	CC(C)(C)C1=C2C(C(O)(C(F)(F)F)C(O2)=O)=CC(C(C)(C)C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for rac BHFF

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.03	100
	ethanol	33.03	100

Preparing Stock Solutions for rac BHFF

The following data is based on the product molecular weight 330.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.03 mL	15.14 mL	30.27 mL
5 mM	0.61 mL	3.03 mL	6.05 mL
10 mM	0.30 mL	1.51 mL	3.03 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

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References for rac BHFF

References are publications that support the biological activity of the product.

Koek Discriminative stimulus effects of the GABA_B receptor-positive modulator rac-BHFF: comparison with GABA_B receptor agonists and drugs of abuse. J.Pharmacol.Exp.Ther. 2013 PMID: 23275067
Malherbe Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABA_B receptors. Br.J.Pharmacol. 2008 PMID: 18536733