RI-STAD 2

Name: RI-STAD 2
Brand: Tocris Bioscience
SKU: 6567

Tocris Bioscience, part of Bio-Techne | Catalog # 6567

COA / SDS

AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable

Discontinued Product

6567 has been discontinued. View all AKAP Inhibitors products.

Key Product Details

Description:	AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable
Molecular Weight:	2401.75

View Full Technical Details for RI-STAD 2

Technical Data
Citations

Biological Activity for RI-STAD 2

RI-STAD 2 is an AKAP disruptor. Selectively binds PKA-RI with high affinity (K_D values are 6.2 and 12.1 nM for the RIα and β subunits, respectively) and blocks its interaction with AKAP. Inhibits type I PKA-mediated phosphorylation in live cells. Cell permeable.

Technical Data for RI-STAD 2

M. Wt	2401.75
Formula	C₁₀₉H₁₈₁N₂₅O₃₅
Single Letter Sequence	LXQYAXQLADQIIKEATEK (Modifications: Leu-1 = NH2-PEG3-CH2-CO-Leu, X = (S)-2-(4-pentenyl)alanine, X-2 and X-6 stapled together with a double bond)
Storage	Store at -20°C
Smiles	O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@](CCC/C=C/CCC[C@](NC([C@H](CC(C)C)NC(COCCOCCOCCN)=O)=O)(C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@H]2C)=O)=O)=O)C)(NC2=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for RI-STAD 2

References are publications that support the biological activity of the product.

Wang PKA-type I selective constrained peptide disruptors of AKAP complexes. ACS Chem.Biol. 2015 PMID: 25765284

RI-STAD 2

Tocris Bioscience, part of Bio-Techne | Catalog # 6567

Key Product Details

Biological Activity for RI-STAD 2

Technical Data for RI-STAD 2

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for RI-STAD 2

Product Documents for RI-STAD 2

COA

Certificate of Analysis

SDS

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