Rilmenidine hemifumarate

Name: Rilmenidine hemifumarate
Brand: Tocris Bioscience
SKU: 0790

Tocris Bioscience, part of Bio-Techne | Catalog # 0790

Citations (3)

COA / SDS

I1 ligand. Also α2 agonist

Key Product Details

Chemical Name:	2-[N-(Dicyclopropylmethyl)amino]oxazoline hemifumarate
Purity:	≥98%

View Full Technical Details for Rilmenidine hemifumarate

Technical Data
Citations

Biological Activity for Rilmenidine hemifumarate

Rilmenidine hemifumarate is an I₁-imidazoline binding site selective ligand and α₂-adrenoceptor agonist. Possesses greater I₁ vs α₂ selectivity than the prototypical compound, clonidine. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.

Technical Data for Rilmenidine hemifumarate

Formula	C₁₀H₁₆N₂O.½C₄H₄O₄
Storage	Store at -20°C
Purity	≥98%
CAS Number	207572-68-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Rilmenidine hemifumarate

Solubility

Soluble Soluble to 25 mM in DMSO

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References for Rilmenidine hemifumarate

References are publications that support the biological activity of the product.

Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
Williams et al. Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat.Chem.Biol., 2008;4:295 PMID: 18391949
Bricca et al. Rilmenidine selectivity for imidazoline receptors in human brain. Eur.J.Pharmacol., 1989;163:373 PMID: 2566507
Mammoto et al. Antiarrhythmic action of rilmenidine on adrenaline-induced arrhythmia via central imidazoline receptors in halothane-anaesthetized dogs. Br.J.Pharmacol., 1996;117:1744 PMID: 8732285
Michel and Ernsberger Keeping an eye on the I site: imidazoline-preferring receptors. TIPS, 1992;13:369 PMID: 1413085
Bricca et al. Human brain imidazoline receptors: Further characterisation with [³H] clon. Eur.J.Pharmacol., 1994;266:25 PMID: 8137880

Rilmenidine hemifumarate

Tocris Bioscience, part of Bio-Techne | Catalog # 0790

Key Product Details

Biological Activity for Rilmenidine hemifumarate

Technical Data for Rilmenidine hemifumarate

Solubility for Rilmenidine hemifumarate

Dilution Calculator

Reconstitution Calculator

References for Rilmenidine hemifumarate

Product Documents for Rilmenidine hemifumarate

COA

Certificate of Analysis

SDS

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