Rivastigmine tartrate

Name: Rivastigmine tartrate
Brand: Tocris Bioscience
SKU: 4440

Tocris Bioscience, part of Bio-Techne | Catalog # 4440

Citations (5)

COA / SDS

Dual AChE and BChE inhibitor

Key Product Details

Description:	Dual AChE and BChE inhibitor
Alternative Names:	ENA 713
Chemical Name:	N-Ethyl-N-methylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester (2R,3R)-2,3-dihydroxybutanedioate
Purity:	≥99% (HPLC)
Molecular Weight:	400.42

View Full Technical Details for Rivastigmine tartrate

Technical Data
Citations

Biological Activity for Rivastigmine tartrate

Rivastigmine tartrate is a cholinesterase inhibitor; inhibits both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC₅₀ ranges are 4.3-4760 nM and 16-238 nM respectively). Rivastigmine increases α-secretase activity and directs APP processing to the non-amyloidogenic pathway. Brain penetrant.

Compound Libraries for Rivastigmine tartrate

Rivastigmine tartrate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Rivastigmine tartrate

M. Wt	400.42
Formula	C₁₄H₂₂N₂O₂.C₄H₆O₆
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	129101-54-8
PubChem ID	6918078
InChi Key	GWHQHAUAXRMMOT-MBANBULQSA-N
Smiles	O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN(C)C(=O)OC1=CC=CC(=C1)[C@H](C)N(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Rivastigmine tartrate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	40.04	100
	DMSO	40.04	100

Preparing Stock Solutions for Rivastigmine tartrate

The following data is based on the product molecular weight 400.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.50 mL	12.49 mL	24.97 mL
5 mM	0.50 mL	2.50 mL	4.99 mL
10 mM	0.25 mL	1.25 mL	2.50 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for Rivastigmine tartrate

References are publications that support the biological activity of the product.

Brus J.Med.Chem. 2014 PMID: 25226236
Bailey Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. PLoS One 2011 PMID: 21799757
Luo Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J.Med.Chem. 2006 PMID: 16570913
Mehta New acetylcholinesterase inhibitors for Alzheimer's disease. Int.J.Alzheimers Dis 2012 PMID: 22216416
Groner The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates. Mol.Pharmacol. 2007 PMID: 17347320