RN 1747

Name: RN 1747
Brand: Tocris Bioscience
SKU: 3745

Tocris Bioscience, part of Bio-Techne | Catalog # 3745

Citations (10)

COA / SDS

Selective TRPV4 agonist

Key Product Details

Chemical Name:	1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine
Purity:	≥98%
Molecular Weight:	395.87 kDa

View Full Technical Details for RN 1747

Technical Data
Citations

Biological Activity for RN 1747

RN 1747 is a selective TRPV4 agonist (EC₅₀ values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC₅₀ values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC₅₀ = 4 μM).

Technical Data for RN 1747

M. Wt	395.87 kDa
Formula	C₁₇H₁₈ClN₃O₄S
Storage	Store at +4°C
Purity	≥98%
CAS Number	1024448-59-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RN 1747

Solubility

Soluble Soluble to 100 mM in DMSO

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for RN 1747

References are publications that support the biological activity of the product.

Vincent et al. Identification and characterization of novel TRPV4 modulators. Biochem.Biophys.Res.Comms., 2009;389:490 PMID: 19737537