(RS)-Baclofen

Name: ( RS )-Baclofen
Brand: Tocris Bioscience
SKU: 0417
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0417

(1)

Citations (51)

COA / SDS

Selective GABAB agonist

Key Product Details

Description:	Selective GABA_B agonist
Chemical Name:	(RS)-4-Amino-3-(4-chlorophenyl)butanoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	213.66

View Full Technical Details for (RS)-Baclofen

Technical Data
Citations / Reviews (1)

Biological Activity for (RS)-Baclofen

(RS)-Baclofen is a selective GABA_B receptor agonist. Skeletal muscle relaxant.

R-enantiomer also available.

Technical Data for (RS)-Baclofen

M. Wt	213.66
Formula	C₁₀H₁₂ClNO₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1134-47-0
PubChem ID	2284
InChi Key	KPYSYYIEGFHWSV-UHFFFAOYSA-N
Smiles	OC(CC(CN)C1=CC=C(Cl)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (RS)-Baclofen

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH		100

Preparing Stock Solutions for (RS)-Baclofen

The following data is based on the product molecular weight 213.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.68 mL	23.40 mL	46.80 mL
5 mM	0.94 mL	4.68 mL	9.36 mL
10 mM	0.47 mL	2.34 mL	4.68 mL
50 mM	0.09 mL	0.47 mL	0.94 mL

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Reconstitution Calculator

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References for (RS)-Baclofen

References are publications that support the biological activity of the product.

Bowery GABA_B receptor pharmacology. Annu.Rev.Pharmacol.Toxicol. 1993 PMID: 8388192
Hill ³H-Baclofen and ³H-GABA bind to bicuculline-insensitive GABA_B sites in rat brain. Nature 1981 PMID: 6259535
Berthelot 3-Thienylaminobutyric acid and 3-furylaminobutyric acids - synthesis and GABA_B receptor binding studies. J.Med.Chem. 1991 PMID: 1652022