S 24795

Name: S 24795
Brand: Tocris Bioscience
SKU: 3518

Tocris Bioscience, part of Bio-Techne | Catalog # 3518

COA / SDS

α7 nAChR partial agonist

Key Product Details

Description:	α7 nAChR partial agonist
Chemical Name:	2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide
Purity:	≥99% (HPLC)
Molecular Weight:	418.07

View Full Technical Details for S 24795

Technical Data
Citations

Biological Activity for S 24795

S 24795 is a partial agonist of α7 nAChR. Improves mnemonic function in aged mice for the treatment of aging-related memory disturbances. Displays more efficient memory-enhancing effects than memantine (Cat. No. 0773) in Alzheimer's disease mouse models.

Technical Data for S 24795

M. Wt	418.07
Formula	C₁₄H₁₃BrINO
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	304679-75-2
PubChem ID	9888248
InChi Key	LERUHBBUGAOYOD-UHFFFAOYSA-M
Smiles	BrC1=CC=C(C(CC2=[N+](C)C=CC=C2)=O)C=C1.[I-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for S 24795

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	4.18	10 with gentle warming
	DMSO	41.81	100

Preparing Stock Solutions for S 24795

The following data is based on the product molecular weight 418.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.39 mL	11.96 mL	23.92 mL
5 mM	0.48 mL	2.39 mL	4.78 mL
10 mM	0.24 mL	1.20 mL	2.39 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for S 24795

References are publications that support the biological activity of the product.

Marighetto Comparative effects of the α7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice. Psychopharmacology. 2008 PMID: 18265960
Beracochea Improvement of contextual memory by S 24795 in aged mice: comparison with Mem.. Psychopharmacology 2008 PMID: 18034231
Lagostena The partial α7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus. Neuropharmacology 2008 PMID: 18187166