(S)-SNAP 5114

Name: ( S )-SNAP 5114
Brand: Tocris Bioscience
SKU: 1561
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1561

(1)

Citations (15)

COA / SDS

GABA uptake inhibitor

Key Product Details

Description:	GABA uptake inhibitor
Chemical Name:	1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-(S)-3-piperidinecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	505.61

View Full Technical Details for (S)-SNAP 5114

Technical Data
Citations / Reviews (1)

Biological Activity for (S)-SNAP 5114

(S)-SNAP 5114 is a GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC₅₀ values are 5, 21 and 388 μM for hGAT-3, rGAT-2 and hGAT-1 respectively). Increases thalamic GABA levels and is an anticonvulsant following systemic administration in vivo.

Technical Data for (S)-SNAP 5114

M. Wt	505.61
Formula	C₃₀H₃₅NO₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	157604-55-2
PubChem ID	10458835
InChi Key	VDLDUZLDZBVOAS-QFIPXVFZSA-N
Smiles	O=[C@]([C@@H]1CN(CCOC(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C2=CC=C(OC)C=C2)CCC1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (S)-SNAP 5114

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	25.28	50
	DMSO	50.56	100

Preparing Stock Solutions for (S)-SNAP 5114

The following data is based on the product molecular weight 505.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.98 mL	9.89 mL	19.78 mL
5 mM	0.40 mL	1.98 mL	3.96 mL
10 mM	0.20 mL	0.99 mL	1.98 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for (S)-SNAP 5114

References are publications that support the biological activity of the product.

Borden GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem.Int. 1996 PMID: 8939442
Dalby GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology 2000 PMID: 10974324
Borden Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. Receptors Channels 1994 PMID: 7874447