Sanguinarine chloride

Name: Sanguinarine chloride
Brand: Tocris Bioscience
SKU: 2302

Tocris Bioscience, part of Bio-Techne | Catalog # 2302

Citations (13)

COA / SDS

Inhibitor of protein phosphatase 2C (PP2C)

Key Product Details

Description:	Inhibitor of protein phosphatase 2C (PP2C)
Chemical Name:	13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride
Purity:	≥97% (HPLC)
Molecular Weight:	367.78

View Full Technical Details for Sanguinarine chloride

Technical Data
Citations

Biological Activity for Sanguinarine chloride

Sanguinarine chloride is an inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro. Also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) (IC₅₀ = 10 μM). Plant alkaloid that exhibits anti-inflammatory and antioxidant activity. Blocks cell cycle in the G₁ phase; inhibits cell growth in human prostate carcinoma cells.

Technical Data for Sanguinarine chloride

M. Wt	367.78
Formula	C₂₀H₁₄ClNO₄
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	5578-73-4
PubChem ID	68635
InChi Key	GIZKAXHWLRYMLE-UHFFFAOYSA-M
Smiles	C[N+]1=CC4=C(C=CC5=C4OCO5)C3=C1C2=CC(OCO6)=C6C=C2C=C3.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sanguinarine chloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.68	10

Preparing Stock Solutions for Sanguinarine chloride

The following data is based on the product molecular weight 367.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.19 mL	135.95 mL	271.90 mL
0.5 mM	5.44 mL	27.19 mL	54.38 mL
1 mM	2.72 mL	13.60 mL	27.19 mL
5 mM	0.54 mL	2.72 mL	5.44 mL

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References for Sanguinarine chloride

References are publications that support the biological activity of the product.

Aburai Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells. Biosci.Biotechnol.Biochem. 2010 PMID: 20208361
Adhami Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery. Mol.Cell Ther.
Vogt The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor ofm mitogen-activated protein kinase phosphatase-1. J.Biol.Chem. 2005 PMID: 15753082