SB 216641 hydrochloride

Name: SB 216641 hydrochloride
Brand: Tocris Bioscience
SKU: 1242
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1242

(1)

Citations (7)

COA / SDS

Selective h5-HT1B antagonist

Key Product Details

Description:	Selective h5-HT_1B antagonist
Chemical Name:	N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	523.03

View Full Technical Details for SB 216641 hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for SB 216641 hydrochloride

SB 216641 hydrochloride is a selective h5-HT_1B antagonist with approximately 25-fold selectivity over h5-HT_1D and little or no affinity for a range of other receptor types.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data for SB 216641 hydrochloride

M. Wt	523.03
Formula	C₂₈H₃₀N₄O₄.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	193611-67-5
PubChem ID	10392025
InChi Key	JPBMDMNORXKGHZ-UHFFFAOYSA-N
Smiles	Cl.COC1=C(OCCN(C)C)C=C(NC(=O)C2=CC=C(C=C2)C2=CC=C(C=C2C)C2=NOC(C)=N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 216641 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	26.15	50

Preparing Stock Solutions for SB 216641 hydrochloride

The following data is based on the product molecular weight 523.03.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.82 mL	19.12 mL	38.24 mL
2.5 mM	0.76 mL	3.82 mL	7.65 mL
5 mM	0.38 mL	1.91 mL	3.82 mL
25 mM	0.08 mL	0.38 mL	0.76 mL

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References for SB 216641 hydrochloride

References are publications that support the biological activity of the product.

Price SB-216641 and BRL-15572 - compounds to pharmacologically discriminate h5-HT_1B and h5-HT_1D receptors. Naunyn Schmiedebergs Arch.Pharmacol. 1997 PMID: 930567
Schlicker Effects of selective h5-HT_1B (SB-216641) and 5-HT_1D (BRL-15572) receptor ligands on guinea pig and human 5-HT auto- and heteroreceptors. Naunyn Schmiedebergs Arch.Pharmacol. 1997 PMID: 9303568
Hagan Stimulation of 5-HT_1B receptors causes hypothermia in the guinea pig. Eur.J.Pharmacol. 1997 PMID: 9274976