SB 221284

Name: SB 221284
Brand: Tocris Bioscience
SKU: 1379

Tocris Bioscience, part of Bio-Techne | Catalog # 1379

COA / SDS

Potent and selective 5-HT2B and 5-HT2C antagonist

Discontinued Product

1379 has been discontinued. View all 5-HT2C Receptor Antagonists products.

Key Product Details

Description:	Potent and selective 5-HT_2B and 5-HT_2C antagonist
Chemical Name:	2,3-Dihydro-5-(methylthio)-N-3-pyridinyl-6-(trifluoromethyl)-1H-indole-1-carboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	353.36

View Full Technical Details for SB 221284

Technical Data
Citations

Biological Activity for SB 221284

SB 221284 is a potent, selective 5-HT_2C/2B receptor antagonist. pK_i values are 6.4, 7.9 and 8.6 for 5-HT_2A, _2B and _2C receptors respectively. Centrally active upon systemic administration in vivo.

Licensing Information

Sold under license

Technical Data for SB 221284

M. Wt	353.36
Formula	C₁₆H₁₄F₃N₃OS
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	196965-14-7
PubChem ID	443389
InChi Key	OQZOXHCRSXYSPM-UHFFFAOYSA-N
Smiles	CSC1=C(C=C2N(CCC2=C1)C(=O)NC1=CC=CN=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SB 221284

References are publications that support the biological activity of the product.

Bromidge Novel and selective 5-HT_2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines. J.Med.Chem. 1998 PMID: 9572885
Hutson Activation of mesolimbic DA function by phencyclidine is enhanced by 5-HT_2C/2B receptor antagonists: neurochemical and behavioural studies. Neuropharmacology 2000 PMID: 10974315
Bristow Evidence for accelerated desensitisation of 5-HT_2C receptors following combined treatment with fluox. and the 5-HT_1A receptor antagonist, WAY 100,635, in the rat. Neuropharmacology 2000 PMID: 10760364