SB 222200

Name: SB 222200
Brand: Tocris Bioscience
SKU: 1393
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1393

Citations (41)

COA / SDS

Potent, selective non-peptide NK3 antagonist. Brain penetrant

Key Product Details

Description:	Potent, selective non-peptide NK₃ antagonist. Brain penetrant
Chemical Name:	3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	380.48

View Full Technical Details for SB 222200

Technical Data
Citations

Biological Activity for SB 222200

SB 222200 is a potent and selective non-peptide NK₃ receptor antagonist (K_i values are 4.4, > 100,000 and 250 nM for human NK₃, NK₁ and NK₂ receptors respectively). Antihypertensive in vivo. Brain penetrant.

Licensing Information

Sold under license

Compound Libraries for SB 222200

SB 222200 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SB 222200

M. Wt	380.48
Formula	C₂₆H₂₄N₂O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	174635-69-9
PubChem ID	6604009
InChi Key	MQNYRKWJSMQECI-QFIPXVFZSA-N
Smiles	O=C(C2=C(C)C(C4=CC=CC=C4)=NC3=CC=CC=C23)N[C@@H](CC)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 222200

	Solvent	Max Conc. mM
Solubility
	DMSO	100
	ethanol	100

Preparing Stock Solutions for SB 222200

The following data is based on the product molecular weight 380.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.63 mL	13.14 mL	26.28 mL
5 mM	0.53 mL	2.63 mL	5.26 mL
10 mM	0.26 mL	1.31 mL	2.63 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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References for SB 222200

References are publications that support the biological activity of the product.

Sarau Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist. J.Pharmacol.Exp.Ther. 2000 PMID: 10992004
De Brito Gariepy and Couture Blockade of tachykinin NK3 receptor reverses hypertension through a DArgic mechanism in the ventral tegmental area of spontaneously hypertensive rats. Br.J.Pharmacol. 2010 PMID: 20804497
Medhurst In vitro and in vivo characterization of NK₃ receptors in the rabbit eye by use of selective non-peptide NK₃ receptor antagonists. Br.J.Pharmacol. 1997 PMID: 9351503