SB 258585 hydrochloride

Name: SB 258585 hydrochloride
Brand: Tocris Bioscience
SKU: 1961

Tocris Bioscience, part of Bio-Techne | Catalog # 1961

Citations (4)

COA / SDS

Potent, selective 5-HT6 antagonist

Key Product Details

Description:	Potent, selective 5-HT₆ antagonist
Chemical Name:	4-Iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]benzenesulfonamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	523.82

View Full Technical Details for SB 258585 hydrochloride

Technical Data
Citations

Biological Activity for SB 258585 hydrochloride

SB 258585 hydrochloride is a potent and selective 5-HT₆ receptor antagonist (pK_i = 8.6); displays > 160-fold selectivity over other 5-HT receptor subtypes.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for SB 258585 hydrochloride

M. Wt	523.82
Formula	C₁₈H₂₂IN₃O₃S.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1216468-02-8
PubChem ID	53429667
InChi Key	BFGOZFXMAJBFGI-UHFFFAOYSA-N
Smiles	Cl.COC1=CC=C(NS(=O)(=O)C2=CC=C(I)C=C2)C=C1N1CCN(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 258585 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	5.24	10
	DMSO	26.19	50

Preparing Stock Solutions for SB 258585 hydrochloride

The following data is based on the product molecular weight 523.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.82 mL	19.09 mL	38.18 mL
2.5 mM	0.76 mL	3.82 mL	7.64 mL
5 mM	0.38 mL	1.91 mL	3.82 mL
25 mM	0.08 mL	0.38 mL	0.76 mL

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References for SB 258585 hydrochloride

References are publications that support the biological activity of the product.

East 5-HT₆ receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [¹²⁵I]SB-258585. Synapse 2002 PMID: 12112397
Hirst Characterization of [¹²⁵I]-SB-258585 binding to human recombinant and native 5-HT₆ receptors in rat, pig and human brain tissue. Br.J.Pharmacol. 2000 PMID: 10928963
Bromidge 5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046): a potent, selective, and orally bioavailable 5-HT₆ receptor antagonist. J.Med.Chem. 1999 PMID: 9925723