SB 674042

Name: SB 674042
Brand: Tocris Bioscience
SKU: 4673

Tocris Bioscience, part of Bio-Techne | Catalog # 4673

Citations (4)

COA / SDS

Potent and selective non-peptide OX1 antagonist

Key Product Details

Description:	Potent and selective non-peptide OX₁ antagonist
Chemical Name:	[5-(2-Fluorophenyl)-2-methyl-4-thiazolyl][2(S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl-1-pyrrolidinyl]methanone
Molecular Weight:	448.51

View Full Technical Details for SB 674042

Technical Data
Citations

Biological Activity for SB 674042

SB 674042 is a potent and selective non-peptide orexin OX₁ receptor antagonist (K_d = 3.76 nM). Exhibits 100-fold selectivity for OX₁ over OX₂ receptors. Has no effect at serotonergic, dopaminergic, adrenergic or purinergic receptors. Inhibits orexin 1-induced Ca²⁺ mobilization in CHO-DG44 cells stably transfected with the OX₁ receptor.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data for SB 674042

M. Wt	448.51
Formula	C₂₄H₂₁FN₄O₂S
Storage	Store at +4°C
CAS Number	483313-22-0
PubChem ID	10204153
InChi Key	HYBZWVLPALMACV-KRWDZBQOSA-N
Smiles	O=C(C2=C(C5=CC=CC=C5F)SC(C)=N2)N1[C@H](CC3=NN=C(C4=CC=CC=C4)O3)CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 674042

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	44.85	100
	ethanol	44.85	100

Preparing Stock Solutions for SB 674042

The following data is based on the product molecular weight 448.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.23 mL	11.15 mL	22.30 mL
5 mM	0.45 mL	2.23 mL	4.46 mL
10 mM	0.22 mL	1.11 mL	2.23 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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References for SB 674042

References are publications that support the biological activity of the product.

Ellis Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function. Biol.Chem. 2006 PMID: 17015451
Langmead Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br.J.Pharmacol. 2004 PMID: 14691055