SB 743921 hydrochloride

Name: SB 743921 hydrochloride
Brand: Tocris Bioscience
SKU: 5109

Tocris Bioscience, part of Bio-Techne | Catalog # 5109

COA / SDS

Potent kinesin spindle protein (KSP) inhibitor

Discontinued Product

5109 has been discontinued. View all Kinesin Inhibitors products.

Key Product Details

Description:	Potent kinesin spindle protein (KSP) inhibitor
Chemical Name:	N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methylbenzamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	553.52

View Full Technical Details for SB 743921 hydrochloride

Technical Data
Citations

Biological Activity for SB 743921 hydrochloride

SB 743921 hydrochloride is a potent kinesin spindle protein (KSP) inhibitor (K_i = 0.1 nM). Induces cell mitotic arrest and apoptosis in vitro. Inhibits the growth of a range of tumor cells in vitro, including colon (HCT 116), prostate (PC-3) and leukemia (K-562) cancer cell lines. Causes tumor regression in human tumor xenograft models in vivo, including colon (Colo205), lung (H69) and breast (MCF7) cancer cell xenografts.

Licensing Information

Sold with the permission of GlaxoSmithKline.

Technical Data for SB 743921 hydrochloride

M. Wt	553.52
Formula	C₃₁H₃₃ClN₂O₃.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	940929-33-9
PubChem ID	49867937
InChi Key	MLMZVWABFOLFGV-LNLSOMNWSA-N
Smiles	ClC1=CC=C2C(OC([C@@H]([C@H](C)C)N(C(C4=CC=C(C)C=C4)=O)CCCN)=C(CC3=CC=CC=C3)C2=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SB 743921 hydrochloride

References are publications that support the biological activity of the product.

Good Optimized S-trityl-_L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models. J.Med.Chem. 2013 PMID: 23394180
Talapatra Mitotic kinesin Eg5 overcomes inhibition to the phase I/II clinical candidate SB743921 by an allosteric resistance mechanism. J.Med.Chem. 2013 PMID: 23875972
Jackson A second generation KSP inhibitor, SB-743921, is a highly potent and active therapeutic in preclinical models of cancer. First AACR International Conference on Molecular and Diagnostics in Cancer Therapeutic Development.