SCH 221510

Name: SCH 221510
Brand: Tocris Bioscience
SKU: 3240

Tocris Bioscience, part of Bio-Techne | Catalog # 3240

Citations (13)

COA / SDS

Potent and selective NOP agonist

Key Product Details

Description:	Potent and selective NOP agonist
Chemical Name:	3-Endo-8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol
Purity:	≥99% (HPLC)
Molecular Weight:	397.55

View Full Technical Details for SCH 221510

Technical Data
Citations

Biological Activity for SCH 221510

SCH 221510 is a potent and selective nociceptin opioid receptor (NOP) agonist (EC₅₀ values are 12, 693, 683 and 8071 nM, and K_i values are 0.3, 65, 131 and 2854 nM at NOP, μ-, κ- and δ-opioid receptors respectively). Exhibits anxiolytic-like activity at doses that have no effect on overt behaviors such as locomotion in vivo. Orally active.

Compound Libraries for SCH 221510

SCH 221510 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SCH 221510

M. Wt	397.55
Formula	C₂₈H₃₁NO
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	322473-89-2
PubChem ID	9887077
InChi Key	LOSJNRBXNQTUNT-UHFFFAOYSA-N
Smiles	OC1(C2=CC=CC=C2)CC3N(C(C5=CC=CC=C5C)C4=C(C)C=CC=C4)C(CC3)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SCH 221510

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.76	100

Preparing Stock Solutions for SCH 221510

The following data is based on the product molecular weight 397.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.52 mL	12.58 mL	25.15 mL
5 mM	0.50 mL	2.52 mL	5.03 mL
10 mM	0.25 mL	1.26 mL	2.52 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for SCH 221510

References are publications that support the biological activity of the product.

Lambert The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential. Nat.Rev.Drug Discov. 2008 PMID: 18670432
Yang Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the management of cough and anxiety. Bioorg.Med.Chem.Lett. 2009 PMID: 19332374
Varty The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510). J.Pharmacol.Exp.Ther. 2008 PMID: 18492950