SCH 28080

Name: SCH 28080
Brand: Tocris Bioscience
SKU: 1690

Tocris Bioscience, part of Bio-Techne | Catalog # 1690

Citations (8)

COA / SDS

H+,K+-ATPase inhibitor

Key Product Details

Description:	H⁺,K⁺-ATPase inhibitor
Chemical Name:	2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile
Purity:	≥99% (HPLC)
Molecular Weight:	277.33

View Full Technical Details for SCH 28080

Technical Data
Citations

Biological Activity for SCH 28080

SCH 28080 is a potent inhibitor of H⁺,K⁺-ATPase (IC₅₀ = 20 nM); binds to the K⁺ recognition site and is competitive with respect to K⁺. Inhibits gastric acid secretion in vitro and in vivo.

Technical Data for SCH 28080

M. Wt	277.33
Formula	C₁₇H₁₅N₃O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	76081-98-6
PubChem ID	108137
InChi Key	PYKJFEPAUKAXNN-UHFFFAOYSA-N
Smiles	CC1=C(CC#N)N2C=CC=C(OCC3=CC=CC=C3)C2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SCH 28080

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	2.77	10
	DMSO	6.93	25

Preparing Stock Solutions for SCH 28080

The following data is based on the product molecular weight 277.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	14.42 mL	72.12 mL	144.23 mL
1.25 mM	2.88 mL	14.42 mL	28.85 mL
2.5 mM	1.44 mL	7.21 mL	14.42 mL
12.5 mM	0.29 mL	1.44 mL	2.88 mL

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Reconstitution Calculator

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References for SCH 28080

References are publications that support the biological activity of the product.

Scott Studies on the mechanism of action of the gastric microsomal (H⁺K⁺)-ATPase inhibitors SCH 32651 and SCH 28080. Biochem.Pharmacol. 1987 PMID: 3026407
Vagin SCH 28080, a K⁺-competitive inhibitor of the gastric H,K-ATPase, binds near the M5-6 luminal loop, preventing K⁺ access to the ion binding domain. Biochemistry 2002 PMID: 12379118
Long Gastric antisecretory and cytoprotective activities of SCH 28080. J.Pharmacol.Exp.Ther. 1983 PMID: 6864535