Scopolamine hydrobromide

Name: Scopolamine hydrobromide
Brand: Tocris Bioscience
SKU: 1414

Tocris Bioscience, part of Bio-Techne | Catalog # 1414

Citations (73)

COA / SDS

Non-selective muscarinic antagonist

Key Product Details

Description:	Non-selective muscarinic antagonist
Chemical Name:	(α,S)-α-(Hydroxymethyl)benzeneacetic acid (1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester hydrobromide
Purity:	≥99% (HPLC)
Molecular Weight:	384.27

View Full Technical Details for Scopolamine hydrobromide

Technical Data
Citations

Biological Activity for Scopolamine hydrobromide

Scopolamine hydrobromide is a non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.

Technical Data for Scopolamine hydrobromide

M. Wt	384.27
Formula	C₁₇H₂₁NO₄.HBr
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	114-49-8
PubChem ID	45073445
InChi Key	WMRMIRRDPBKNMY-ZEECNFPPSA-N
Smiles	O=C([C@@H]([C@]3=CC=CC=C3)CO)O[C@H]1C[C@H]4[C@H](O2)[C@H]2[C@H](N4C)C1.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Scopolamine hydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	38.43	100
	DMSO	19.21	50

Preparing Stock Solutions for Scopolamine hydrobromide

The following data is based on the product molecular weight 384.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.60 mL	13.01 mL	26.02 mL
5 mM	0.52 mL	2.60 mL	5.20 mL
10 mM	0.26 mL	1.30 mL	2.60 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for Scopolamine hydrobromide

References are publications that support the biological activity of the product.

Nakao Cerebral blood flow responses to somatosensory stimulation are unaffected by scopol. in unanesthetized rat. J.Pharmacol.Exp.Ther. 1999 PMID: 10411611
Parkes An examination of central actions characteristic of scopolamine: comparison of central and peripheral activity in scopolamine, atr. and some synthetic basic esters. Psychopharmacologia 1965 PMID: 5830966
Jones and Shannon Effects of scopol. in comparison with apomor. and phencyclidine on prepulse inhibition in rats. Eur.J.Pharmacol. 2000 PMID: 10720641