SDZ NKT 343

Name: SDZ NKT 343
Brand: Tocris Bioscience
SKU: 2394

Tocris Bioscience, part of Bio-Techne | Catalog # 2394

Citations (2)

COA / SDS

Highly selective human NK1 antagonist

Key Product Details

Description:	Highly selective human NK₁ antagonist
Chemical Name:	1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide
Purity:	≥98% (HPLC)
Molecular Weight:	579.65

View Full Technical Details for SDZ NKT 343

Technical Data
Citations

Biological Activity for SDZ NKT 343

SDZ NKT 343 is a highly selective human tachykinin NK₁ receptor antagonist (IC₅₀ values are 0.62 and 451 nM for human and rat receptors respectively) that displays > 130-fold selectivity over human NK₂ and NK₃ receptors. Potently antagonizes SP-induced Ca²⁺ efflux in vitro and inhibits mechanical hyperalgesia in vivo.

Compound Libraries for SDZ NKT 343

SDZ NKT 343 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SDZ NKT 343

M. Wt	579.65
Formula	C₃₃H₃₃N₅O₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	180046-99-5
PubChem ID	9851211
InChi Key	PCVSIMQAFWRUEC-JDXGNMNLSA-N
Smiles	O=C(NC3=C([N+]([O-])=O)C=CC=C3)N1[C@H]([C@@](N[C@H]([C@@](N(C)CC4=CC=CC=C4)=O)CC2=CC=C(C=CC=C5)C5=C2)=O)CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SDZ NKT 343

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	57.97	100
	ethanol	57.97	100

Preparing Stock Solutions for SDZ NKT 343

The following data is based on the product molecular weight 579.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.73 mL	8.63 mL	17.25 mL
5 mM	0.35 mL	1.73 mL	3.45 mL
10 mM	0.17 mL	0.86 mL	1.73 mL
50 mM	0.03 mL	0.17 mL	0.35 mL

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References for SDZ NKT 343

References are publications that support the biological activity of the product.

Walpole 2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N-methylamide (SDZ NKT 343), a potent human NK1 tachykinin receptor antagonist with good oral analgesic activity in chronic pain models. J.Med.Chem. 1998 PMID: 9703462
Campbell Selective neurokinin-1 receptor antagonists are anti-hyperalgesic in a model of neuropathic pain in the guinea-pig. Neuroscience. 1998 PMID: 9758219
Walpole Comparative, general pharmacology of SDZ NKT 343, a novel, selective NK1 receptor antagonist. Br.J.Pharmacol. 1998 PMID: 9630347