SDZ WAG 994

Name: SDZ WAG 994
Brand: Tocris Bioscience
SKU: 2465

Tocris Bioscience, part of Bio-Techne | Catalog # 2465

Citations (2)

COA / SDS

Potent and selective A1 agonist

Key Product Details

Chemical Name:	N-Cyclohexyl-2'-O-methyladenosine
Purity:	≥99%
Molecular Weight:	363.41 kDa

View Full Technical Details for SDZ WAG 994

Technical Data
Citations

Biological Activity for SDZ WAG 994

SDZ WAG 994 is a potent and selective A₁ adenosine receptor agonist (K_i values are 23, > 10000 and 25000 nM for A₁, A_2A and A_2B receptors respectively). Causes a sustained fall in blood pressure and heart rate in spontaneous hypertensive rats and inhibits adenosine deaminase-stimulated lipolysis in rat adipocytes (K_i = 8 nM).

Technical Data for SDZ WAG 994

M. Wt	363.41 kDa
Formula	C₁₇H₂₅N₅O₄
Storage	Desiccate at +4°C
Purity	≥99%
CAS Number	130714-47-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SDZ WAG 994

Solubility

Soluble Soluble to 100 mM in 1.1eq. NaOH and to 100 mM in DMSO

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References for SDZ WAG 994

References are publications that support the biological activity of the product.

Jacobson and Gao Adenosine receptors as therapeutic targets. Nat.Rev.Drug Discov., 2006;5:247 PMID: 16518376
Ishikawa et al. Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A₁ receptor agonist, in spontaneous hypertensive rat complicated with hyperglycemia. Diabetes Res.Clin.Pract., 1998;39:3 PMID: 9597368
Wagner et al. General pharmacology of SDZ WAG 994, a potent selective and orally active adenosine A₁ receptor agonist. Drug Dev.Res., 1995;34:276