SEA 0400

Name: SEA 0400
Brand: Tocris Bioscience
SKU: 6164

Tocris Bioscience, part of Bio-Techne | Catalog # 6164

Citations (14)

COA / SDS

Potent Na+/Ca2+ exchanger (NCX) inhibitor

Key Product Details

Chemical Name:	2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxybenzenamine
Purity:	≥98%

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Technical Data
Citations

Biological Activity for SEA 0400

SEA 0400 is a potent Na⁺/Ca²⁺ exchanger (NCX) inhibitor. Inhibits NCX activity in rat astrocytes, microglia and cultured neurons, canine cardiac sarcolemmal vesicles and rat cardiomyocytes (IC₅₀ values are 5 and 8.3, 33, 90 and 92 nM, respectively). Reduces infarct volumes and exhibits protective effects against myocardial ischemia in rats.

Technical Data for SEA 0400

Formula	C₂₁H₁₉F₂NO₃
Storage	Store at -20°C
Purity	≥98%
CAS Number	223104-29-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SEA 0400

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for SEA 0400

References are publications that support the biological activity of the product.

Christ et al. Block of Na(⁺)/Ca(²⁺) exchanger by SEA0400 in human right atrial preparations from patients in sinus rhythm and in atrial fibrillation. Eur.J.Pharmacol., 2016;788:286 PMID: 27373849
Karashima et al. Involvement of Na⁺-Ca²⁺ exchanger in cAMP-mediated relaxation in mice aorta: evaluation using transgenic mice. Br.J.Pharmacol., 2007;150:343 PMID: 17220909
Takahashi et al. Protective effects of SEA0400, a novel and selective inhibitor of the Na⁺/Ca²⁺ exchanger, on myocardial ischemia-reperfusion injuries. Eur.J.Pharmacol., 2003;458:155 PMID: 12498920

SEA 0400

Tocris Bioscience, part of Bio-Techne | Catalog # 6164

Key Product Details

Biological Activity for SEA 0400

Technical Data for SEA 0400

Solubility for SEA 0400

Dilution Calculator

Reconstitution Calculator

References for SEA 0400

Product Documents for SEA 0400

COA

Certificate of Analysis

SDS

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