Sertraline hydrochloride

Name: Sertraline hydrochloride
Brand: Tocris Bioscience
SKU: 2395

Tocris Bioscience, part of Bio-Techne | Catalog # 2395

Citations (12)

COA / SDS

5-HT reuptake inhibitor

Key Product Details

Description:	5-HT reuptake inhibitor
Chemical Name:	(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	342.69

View Full Technical Details for Sertraline hydrochloride

Technical Data
Citations

Biological Activity for Sertraline hydrochloride

Sertraline is a potent and selective serotonin (5-HT) reuptake inhibitor (SSRI) that is an orally active antidepressant. Sertraline also decreases ergosterol biosynthesis and exhibits antifungal activity against Candida auris in vitro. Sertraline acts as an inhibitor of SHMT(serine hydroxymethyltransferase), inhibiting serine/glycine synthesis and proliferation of serine/glycine synthesis-dependent breast cancer cell lines in vitro and in vivo.

Compound Libraries for Sertraline hydrochloride

Sertraline hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Sertraline hydrochloride

M. Wt	342.69
Formula	C₁₇H₁₇Cl₂N.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	79559-97-0
PubChem ID	63009
InChi Key	BLFQGGGGFNSJKA-XHXSRVRCSA-N
Smiles	ClC(C(Cl)=C3)=CC=[C@@]3[C@H]2C1=CC=CC=C1[C@@H](NC)CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sertraline hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.26	100
	ethanol	17.13	50

Preparing Stock Solutions for Sertraline hydrochloride

The following data is based on the product molecular weight 342.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.92 mL	14.59 mL	29.18 mL
5 mM	0.58 mL	2.92 mL	5.84 mL
10 mM	0.29 mL	1.46 mL	2.92 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References for Sertraline hydrochloride

References are publications that support the biological activity of the product.

Geeraerts Repurposing the antidepressant Sertraline as SHMT inhibitor to suppress serine/glycine synthesis-addicted breast tumor growth. Mol.Cancer Ther. 2021 PMID: 33203732
Gowri Sertraline as a promising antifungal agent: inhibition of growth and biofilm of Candida auris with special focus on the mechanism of action in vitro. J.Appl.Microbiol. 2020 PMID: 31621139
Heym and Koe Pharmacology of sertraline: a review. J.Clin.Psychiatry 1988 PMID: 3045112
Doogan and Caillard Sertraline: a new antidepressant. J.Clin.Psychiatry. 1988 PMID: 2842321
Koe Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin. J.Pharmacol.Exp.Ther. 1983 PMID: 6310078