SGC CK2-1

Name: SGC CK2-1
Brand: Tocris Bioscience
SKU: 7450

Tocris Bioscience, part of Bio-Techne | Catalog # 7450

Citations (2)

COA / SDS

Potent CK2A2 and CK2A1 inhibitor; also inhibits DYRK2

Key Product Details

Description:	Potent CK2A2 and CK2A1 inhibitor; also inhibits DYRK2
Chemical Name:	N-[5-[[3-Cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]propanamide
Purity:	≥98% (HPLC)
Molecular Weight:	375.44

View Full Technical Details for SGC CK2-1

Technical Data
Citations

Biological Activity for SGC CK2-1

SGC CK2-1 is a potent inhibitor of casein kinase 2 (CK2) with activity at both the CK2A2 and CK2A1 isoforms (IC₅₀ values are 2.3-16 nM and 4.2-36 nM respectively). SGC CK-1 also inhibits DYRK2 (IC₅₀ = 440 nM).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC CK2-1 probe summary on the SGC website.

Compound Libraries for SGC CK2-1

SGC CK2-1 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGC CK2-1 is reviewed on the chemical probes website.

Technical Data for SGC CK2-1

M. Wt	375.44
Formula	C₂₀H₂₁N₇O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2470424-39-4
PubChem ID	146681133
InChi Key	YKDZIFFKQUNVHH-UHFFFAOYSA-N
Smiles	CCC(NC1=C(C=CC(NC2=NC3=C(C#N)C=NN3C(NC4CC4)=C2)=C1)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SGC CK2-1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.54	100

Preparing Stock Solutions for SGC CK2-1

The following data is based on the product molecular weight 375.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.66 mL	13.32 mL	26.64 mL
5 mM	0.53 mL	2.66 mL	5.33 mL
10 mM	0.27 mL	1.33 mL	2.66 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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Reconstitution Calculator

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References for SGC CK2-1

References are publications that support the biological activity of the product.

Wells Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chem.Biol. 2021 PMID: 33484635