SID 7969543

Name: SID 7969543
Brand: Tocris Bioscience
SKU: 3440

Tocris Bioscience, part of Bio-Techne | Catalog # 3440

Citations (4)

COA / SDS

Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor

Key Product Details

Description:	Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor
Chemical Name:	Ethyl 2-[[2-[2-[(2,3-Dihydro-1,4-benzodioxin-6-yl)amino]-2-oxoethyl]-1,2-dihydro-1-oxo-5-isoquinolinyl]oxy]propanoate
Purity:	≥98% (HPLC)
Molecular Weight:	452.46

View Full Technical Details for SID 7969543

Technical Data
Citations

Biological Activity for SID 7969543

SID 7969543 is a selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor (IC₅₀ values are 0.76, >33 and >33 μM at SF-1, RORα and VP16 respectively). Inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro (IC₅₀ = 30 nM).

Technical Data for SID 7969543

M. Wt	452.46
Formula	C₂₄H₂₄N₂O₇
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	868224-64-0
PubChem ID	4076092
InChi Key	KWMBIIQCLUIHDI-UHFFFAOYSA-N
Smiles	O=C2C1=CC=CC(OC(C)C(OCC)=O)=C1C=CN2CC(NC3=CC=C(OCCO4)C4=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SID 7969543

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	45.25	100

Preparing Stock Solutions for SID 7969543

The following data is based on the product molecular weight 452.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.21 mL	11.05 mL	22.10 mL
5 mM	0.44 mL	2.21 mL	4.42 mL
10 mM	0.22 mL	1.11 mL	2.21 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for SID 7969543

References are publications that support the biological activity of the product.

Madoux Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol.Pharmacol. 2008 PMID: 18334597
Roth Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds. Bioorg.med.Chem.Lett. 2008 PMID: 18374567