Sirtinol

Name: Sirtinol
Brand: Tocris Bioscience
SKU: 3521

Tocris Bioscience, part of Bio-Techne | Catalog # 3521

Citations (20)

COA / SDS

Selective sirtuin family deacetylase inhibitor

Key Product Details

Description:	Selective sirtuin family deacetylase inhibitor
Chemical Name:	2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	394.47

View Full Technical Details for Sirtinol

Technical Data
Citations

Biological Activity for Sirtinol

Sirtinol is a cell-permeable, selective sirtuin deacetylase inhibitor (IC₅₀ values are 38, 68 and 131 μM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.

Technical Data for Sirtinol

M. Wt	394.47
Formula	C₂₆H₂₂N₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	410536-97-9
PubChem ID	5717148
InChi Key	YUGODMKHHCZZOI-QJOMJCCJSA-N
Smiles	O=C(NC(C)C3=CC=CC=C3)C1=CC=CC=C1/N=C/C2=C(C=CC=C4)C4=CC=C2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sirtinol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.45	100

Preparing Stock Solutions for Sirtinol

The following data is based on the product molecular weight 394.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.54 mL	12.68 mL	25.35 mL
5 mM	0.51 mL	2.54 mL	5.07 mL
10 mM	0.25 mL	1.27 mL	2.54 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Sirtinol

References are publications that support the biological activity of the product.

Jung-Hynes Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J.Biol.Chem. 2009 PMID: 19075016
Mai Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors. J.Med.Chem. 2005 PMID: 16302818
Kahyo A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells. J.Pharmacol.Sci. 2008 PMID: 19008647
Grozinger Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J.Biol.Chem. 2001 PMID: 11483616