SKA 121

Name: SKA 121
Brand: Tocris Bioscience
SKU: 6398

Tocris Bioscience, part of Bio-Techne | Catalog # 6398

COA / SDS

Positive allosteric modulator of KCa3.1 (IK) channels

Key Product Details

Description:	Positive allosteric modulator of K_Ca3.1 (IK) channels
Chemical Name:	5-Methylnaphth[2,1-d]oxazol-2-amine
Purity:	≥98% (HPLC)
Molecular Weight:	198.23

View Full Technical Details for SKA 121

Technical Data
Citations

Biological Activity for SKA 121

SKA 121 is a positive allosteric modulator of K_Ca3.1 (intermediate-conductance Ca²⁺-activated potassium) channels (EC₅₀ = 109 nM). Displays 40-fold selectivity for K_Ca3.1 over K_Ca2.3, and 200 to 400-fold selectivity over K_V and Na_V channels. Potentiates bradykinin-induced vasodilation ex vivo. Lowers mean arterial blood pressure in normotensive and hypertensive mice.

Technical Data for SKA 121

M. Wt	198.23
Formula	C₁₂H₁₀N₂O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1820708-73-3
PubChem ID	91827362
InChi Key	JEGUERWMMMQFJV-UHFFFAOYSA-N
Smiles	NC(O1)=NC2=C1C3=CC=CC=C3C(C)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SKA 121

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	19.82	100
	ethanol	9.91	50

Preparing Stock Solutions for SKA 121

The following data is based on the product molecular weight 198.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.04 mL	25.22 mL	50.45 mL
5 mM	1.01 mL	5.04 mL	10.09 mL
10 mM	0.50 mL	2.52 mL	5.04 mL
50 mM	0.10 mL	0.50 mL	1.01 mL

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References for SKA 121

References are publications that support the biological activity of the product.

Oliván-Viguera Vascular reactivity profile of novel K_Ca 3.1-selective positive-gating modulators in the coronary vascular bed. Basic Clin.Pharmacol.Toxicol. 2016 PMID: 26821335
Coleman New positive Ca²⁺-activated K⁺ channel gating modulators with selectivity for K_Ca3.1. Mol.Pharmacol. 2014 PMID: 24958817