SKF 38393 hydrobromide

Name: SKF 38393 hydrobromide
Brand: Tocris Bioscience
SKU: 0922

Tocris Bioscience, part of Bio-Techne | Catalog # 0922

Citations (20)

COA / SDS

Selective D1-like agonist

Key Product Details

Description:	Selective D₁-like agonist
Chemical Name:	(±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	336.23

View Full Technical Details for SKF 38393 hydrobromide

Technical Data
Citations

Biological Activity for SKF 38393 hydrobromide

SKF 38393 hydrobromide is a prototypical D₁-like dopamine receptor selective partial agonist (K_i values are 1, ~ 0.5, ~ 150, ~ 5000 and ~ 1000 nM for D₁, D₅, D₂, D₃ and D₄ receptors respectively).

Compound Libraries for SKF 38393 hydrobromide

SKF 38393 hydrobromide is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SKF 38393 hydrobromide

M. Wt	336.23
Formula	C₁₆H₁₇NO₂.HBr
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	20012-10-6
PubChem ID	12928470
InChi Key	INNWVRBZMBCEJI-UHFFFAOYSA-N
Smiles	Br.OC1=CC2=C(C=C1O)C(CNCC2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SKF 38393 hydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	8.41	25 with gentle warming
	DMSO	33.62	100

Preparing Stock Solutions for SKF 38393 hydrobromide

The following data is based on the product molecular weight 336.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.97 mL	14.87 mL	29.74 mL
5 mM	0.59 mL	2.97 mL	5.95 mL
10 mM	0.30 mL	1.49 mL	2.97 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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Reconstitution Calculator

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References for SKF 38393 hydrobromide

References are publications that support the biological activity of the product.

Sibley Interactions of novel DArgic ligands with D₁ and D₂ DA receptors. Life Sci. 1982 PMID: 6127585
Habuchi DA stimulation of cardiac β-adrenoceptors: the involvement of sympathetic amine transporters and the effect of SKF38393. Br.J.Pharmacol. 1997 PMID: 9422813
Seeman and Van Tol DA receptor pharmacology. TiPS 1994 PMID: 7940991
Geter-Douglass Characterization of unconditioned behavioral effects of DA D₃/D₂ receptor agonists. J.Pharmacol.Exp.Ther. 1997 PMID: 9336302