SMER 3

Name: SMER 3
Brand: Tocris Bioscience
SKU: 4375

Tocris Bioscience, part of Bio-Techne | Catalog # 4375

Citations (4)

COA / SDS

Selective inhibitor of E3 ubiquitin ligase

Key Product Details

Description:	Selective inhibitor of E3 ubiquitin ligase
Chemical Name:	9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
Purity:	≥98% (HPLC)
Molecular Weight:	224.18

View Full Technical Details for SMER 3

Technical Data
Citations

Biological Activity for SMER 3

SMER 3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCF^Met30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin (Cat. No. 1292).

Compound Libraries for SMER 3

SMER 3 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for SMER 3

M. Wt	224.18
Formula	C₁₁H₄N₄O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	67200-34-4
PubChem ID	568763
InChi Key	SFSSAKVWCKFRHE-UHFFFAOYSA-N
Smiles	O=C4C2=NC1=NON=C1N=C2C3=CC=CC=C34

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SMER 3

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	16.81	75

Preparing Stock Solutions for SMER 3

The following data is based on the product molecular weight 224.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	5.95 mL	29.74 mL	59.48 mL
3.75 mM	1.19 mL	5.95 mL	11.90 mL
7.5 mM	0.59 mL	2.97 mL	5.95 mL
37.5 mM	0.12 mL	0.59 mL	1.19 mL

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Reconstitution Calculator

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References for SMER 3

References are publications that support the biological activity of the product.

Aghajanyy Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor. Nat.Biotechnol. 2010 PMID: 20581845