SNAP 94847 hydrochloride

Name: SNAP 94847 hydrochloride
Brand: Tocris Bioscience
SKU: 3347

Tocris Bioscience, part of Bio-Techne | Catalog # 3347

Citations (4)

COA / SDS

Potent and selective MCH1 antagonist

Key Product Details

Description:	Potent and selective MCH₁ antagonist
Chemical Name:	N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	515.03

View Full Technical Details for SNAP 94847 hydrochloride

Technical Data
Citations

Biological Activity for SNAP 94847 hydrochloride

SNAP 94847 hydrochloride is a potent melanin-concentrating hormone receptor 1 (MCH₁) antagonist (K_i = 2.2 nM, K_D = 530 pM) that displays > 80-fold and > 500-fold selectivity over α_1A and D₂ receptors respectively. Increases neurogenesis in the dentate gyrus and decreases food-reinforced operant responding in vivo. Exhibits anxiolytic activity and is orally active.

Compound Libraries for SNAP 94847 hydrochloride

SNAP 94847 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SNAP 94847 hydrochloride

M. Wt	515.03
Formula	C₂₉H₃₂F₂N₂O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1781934-47-1
PubChem ID	56972235
InChi Key	DEDUDFNRQKUBRH-UHFFFAOYSA-N
Smiles	CC1=CC=C(NC(C(C)C)=O)C=C1C(CC4)CCN4CC(C=C3)=CC=C3OC2=CC(F)=C(F)C=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SNAP 94847 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	51.5	100
	ethanol	51.5	100

Preparing Stock Solutions for SNAP 94847 hydrochloride

The following data is based on the product molecular weight 515.03.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.94 mL	9.71 mL	19.42 mL
5 mM	0.39 mL	1.94 mL	3.88 mL
10 mM	0.19 mL	0.97 mL	1.94 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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References for SNAP 94847 hydrochloride

References are publications that support the biological activity of the product.

David Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of J.Pharmacol.Exp.Ther. 2007 PMID: 17237257
Nair Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats. Psychopharmacology 2009 PMID: 19340414
Chen Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key features of HTS hits. J.Med.Chem. 2007 PMID: 17668922