Sonepiprazole

Name: Sonepiprazole
Brand: Tocris Bioscience
SKU: 4185

Tocris Bioscience, part of Bio-Techne | Catalog # 4185

Citations (2)

COA / SDS

Selective D4 antagonist

Key Product Details

Description:	Selective D₄ antagonist
Alternative Names:	PNU 101387,U 101387
Chemical Name:	4-[4-[2-[(1S)-3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-1-piperazinyl]-benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	401.52

View Full Technical Details for Sonepiprazole

Technical Data
Citations

Biological Activity for Sonepiprazole

Sonepiprazole is a selective, high affinity antagonist for the rat and human dopamine D₄ receptor (K_i = 10 nM). Exhibits low affinity at other monoamine receptors (K_i > 2000 nM). Induces c-fos gene expression in medial prefrontal cortex in a similar manner to clozapine (Cat. No. 0444). Brain penetrant and orally available.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for Sonepiprazole

M. Wt	401.52
Formula	C₂₁H₂₇N₃O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	170858-33-0
PubChem ID	133079
InChi Key	WNUQCGWXPNGORO-NRFANRHFSA-N
Smiles	O=S(C1=CC=C(N2CCN(CC[C@H]3C(C=CC=C4)=C4CCO3)CC2)C=C1)(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sonepiprazole

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.15	100

Preparing Stock Solutions for Sonepiprazole

The following data is based on the product molecular weight 401.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.49 mL	12.45 mL	24.91 mL
5 mM	0.50 mL	2.49 mL	4.98 mL
10 mM	0.25 mL	1.25 mL	2.49 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for Sonepiprazole

References are publications that support the biological activity of the product.

Merchant Pharmacological characterization of U-101387, a DA D₄ receptor selective antagonist. J.Pharmacol.Exp.Ther. 1996 PMID: 8968364