SR 0987

Name: SR 0987
Brand: Tocris Bioscience
SKU: 5868

Tocris Bioscience, part of Bio-Techne | Catalog # 5868

COA / SDS

T cell-specific RORγ (RORγt) agonist

Key Product Details

Description:	T cell-specific RORγ (RORγt) agonist
Chemical Name:	2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	397.7

View Full Technical Details for SR 0987

Technical Data
Citations

Biological Activity for SR 0987

SR 0987 is a T cell-specific RORγ (RORγt) agonist (EC₅₀ = 800 nM in a gene reporter assay). Induces IL-17 expression and decreases PD-1 expression in T cells in vitro.

Compound Libraries for SR 0987

SR 0987 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 0987

M. Wt	397.7
Formula	C₁₆H₁₀ClF₆NO₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	303126-97-8
PubChem ID	2323435
InChi Key	IZVBONMVWLTLNT-UHFFFAOYSA-N
Smiles	OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(C=C1)NC(C2=C(C=CC=C2)Cl)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 0987

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.77	100
	ethanol	39.77	100

Preparing Stock Solutions for SR 0987

The following data is based on the product molecular weight 397.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.51 mL	12.57 mL	25.14 mL
5 mM	0.50 mL	2.51 mL	5.03 mL
10 mM	0.25 mL	1.26 mL	2.51 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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Reconstitution Calculator

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References for SR 0987

References are publications that support the biological activity of the product.

Chang Synthetic RORγt agonists enhance protective immunity. ACS Chem.Biol. 2016 PMID: 26785144