SR 142948

Name: SR 142948
Brand: Tocris Bioscience
SKU: 2309

Tocris Bioscience, part of Bio-Techne | Catalog # 2309

Citations (18)

COA / SDS

Highly potent NTS receptor antagonist

Key Product Details

Description:	Highly potent NTS receptor antagonist
Chemical Name:	2-[[[5-(2,6-Dimethoxyphenyl)-1-[4-[[[3-(dimethylamino)propyl]methylamino]carbonyl]-2-(1-methylethyl)phenyl]-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid
Purity:	≥97% (HPLC)
Molecular Weight:	685.86

View Full Technical Details for SR 142948

Technical Data
Citations

Biological Activity for SR 142948

SR 142948 is a potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC₅₀ = 0.32 - 3.96 nM; K_i < 10 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo.

Compound Libraries for SR 142948

SR 142948 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 142948

M. Wt	685.86
Formula	C₃₉H₅₁N₅O₆
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	184162-64-9
PubChem ID	5311451
InChi Key	LWULHXVBLMWCHO-UHFFFAOYSA-N
Smiles	COC1=CC=CC(OC)=C1C1=CC(=NN1C1=C(C=C(C=C1)C(=O)N(C)CCCN(C)C)C(C)C)C(=O)NC1(C2CC3CC(C2)CC1C3)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 142948

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	51.44	75
	water	17.15	25

Preparing Stock Solutions for SR 142948

The following data is based on the product molecular weight 685.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	1.94 mL	9.72 mL	19.44 mL
3.75 mM	0.39 mL	1.94 mL	3.89 mL
7.5 mM	0.19 mL	0.97 mL	1.94 mL
37.5 mM	0.04 mL	0.19 mL	0.39 mL

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Reconstitution Calculator

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References for SR 142948

References are publications that support the biological activity of the product.

Quere X-ray structural characterization of SR 142948, a novel potent synthetic neurotensin receptor antagonist. Bioorg.Med.Chem.Lett. 1998 PMID: 9871577
Marie-Claire Effects of the selective neurotensin antagonist SR 142948A on 3,4-methylenedioxymethamphetamine-induced behaviours in mice. Neuropharmacology 2008 PMID: 18410947
Gully Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. J.Pharmacol.Exp.Ther. 1997 PMID: 9023294