SR 202

Name: SR 202
Brand: Tocris Bioscience
SKU: 2022

Tocris Bioscience, part of Bio-Techne | Catalog # 2022

Citations (195)

COA / SDS

Selective PPARγ antagonist; antidiabetic and antiobesity agent

Key Product Details

Description:	Selective PPARγ antagonist; antidiabetic and antiobesity agent
Alternative Names:	Mifobate
Chemical Name:	(4-Chlorophenyl)(dimethoxyphosphinyl)methyl phosphoric acid dimethyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	358.65

View Full Technical Details for SR 202

Technical Data
Citations

Biological Activity for SR 202

SR 202 is a selective PPARγ antagonist; antidiabetic and antiobesity agent. Attenuates troglitazone-induced PPARγ transcriptional activity (IC₅₀ = 140 μM) without affecting ligand-stimulated PPARα, PPARβ or FXR transcriptional activity. Inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo. Improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo.

Technical Data for SR 202

M. Wt	358.65
Formula	C₁₁H₁₇ClO₇P₂
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	76541-72-5
PubChem ID	60910
InChi Key	VQHUQHAPWMNBLP-UHFFFAOYSA-N
Smiles	COP(=O)(OC)OC(C1=CC=C(Cl)C=C1)P(=O)(OC)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 202

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	35.87	100

Preparing Stock Solutions for SR 202

The following data is based on the product molecular weight 358.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.79 mL	13.94 mL	27.88 mL
5 mM	0.56 mL	2.79 mL	5.58 mL
10 mM	0.28 mL	1.39 mL	2.79 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for SR 202

References are publications that support the biological activity of the product.

Rieusset A new selective peroxisome proliferator-activated receptor γ antagonist with antiobesity and antidiabetic activity. Mol.Endocrinol. 2002 PMID: 12403851
Doggrell Do peroxisome proliferation receptor-γ antagonists have clinical potential as combined antiobesity and antidiabetic drugs? Expert.Opin.Invest.Drugs
Nguyen gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity. J.Med.Chem. 1987 PMID: 3612689