SR 58611A hydrochloride

Name: SR 58611A hydrochloride
Brand: Tocris Bioscience
SKU: 3986

Tocris Bioscience, part of Bio-Techne | Catalog # 3986

COA / SDS

β3 agonist; displays anxiolytic and antidepressant effects

Key Product Details

Description:	β3 agonist; displays anxiolytic and antidepressant effects
Chemical Name:	[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]ox]yacetic acid ethyl ester hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	440.36

View Full Technical Details for SR 58611A hydrochloride

Technical Data
Citations

Biological Activity for SR 58611A hydrochloride

SR 58611A hydrochloride is a selective β3-adrenergic receptor agonist. Displays both anxiolytic and antidepressant effects in rodent models. Orally active and brain penetrant.

Compound Libraries for SR 58611A hydrochloride

SR 58611A hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 58611A hydrochloride

M. Wt	440.36
Formula	C₂₂H₂₆ClNO₄.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	121524-09-2
PubChem ID	121888
InChi Key	NQIZCDQCNYCVAS-RQBPZYBGSA-N
Smiles	O=C(OCC)COC1=CC=C(CC[C@H](NC[C@H](O)C3=CC(Cl)=CC=C3)C2)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 58611A hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.04	100

Preparing Stock Solutions for SR 58611A hydrochloride

The following data is based on the product molecular weight 440.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.27 mL	11.35 mL	22.71 mL
5 mM	0.45 mL	2.27 mL	4.54 mL
10 mM	0.23 mL	1.14 mL	2.27 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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References for SR 58611A hydrochloride

References are publications that support the biological activity of the product.

Tamburella The beta(3) adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes. Eur.Neuropsychopharmacol. 2010 PMID: 20537869
Claustre Effects of the β3-adrenoceptor (Adrb3) agonist SR58611A (amibegron) on serotonergic and noradrenergic transmission in the rodent: relevance to its antidepressant/anxiolytic-like profile. Neuroscience 2008 PMID: 18691638
Stemmelin Stimulation of the β₃-adrenoceptor as a novel treatment strategy for anxiety and depressive disorders. Neuropsychopharmacology 2008 PMID: 17460614
Consoli Behavioral effects of the β3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs? Eur.J.Pharmacol 2007 PMID: 17669397