SR 8278

Name: SR 8278
Brand: Tocris Bioscience
SKU: 4463

Tocris Bioscience, part of Bio-Techne | Catalog # 4463

Citations (15)

COA / SDS

Rev-Erbα antagonist

Key Product Details

Description:	Rev-Erbα antagonist
Chemical Name:	1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	361.48

View Full Technical Details for SR 8278

Technical Data
Citations

Biological Activity for SR 8278

SR 8278 is a Rev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC₅₀ = 0.47 μM). Blocks activity of Rev-Erbα agonist GSK 4112 (Cat. No. 3663) in HEK293 cells. Increases expression of glucose-regulating genes, G6Pase and PEPCK in HepG2 cells.

Compound Libraries for SR 8278

SR 8278 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 8278

M. Wt	361.48
Formula	C₁₈H₁₉NO₃S₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1254944-66-5
PubChem ID	53393127
InChi Key	UIEBLUZPSFAFOC-UHFFFAOYSA-N
Smiles	CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C1=CC=C(SC)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 8278

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.15	100
	ethanol	18.07	50

Preparing Stock Solutions for SR 8278

The following data is based on the product molecular weight 361.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.83 mL	27.66 mL
5 mM	0.55 mL	2.77 mL	5.53 mL
10 mM	0.28 mL	1.38 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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Reconstitution Calculator

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References for SR 8278

References are publications that support the biological activity of the product.

Kojetin Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem. Biol. 2011 PMID: 21043485