SSYA10-001

Name: SSYA10-001
Brand: Tocris Bioscience
SKU: 7554

Tocris Bioscience, part of Bio-Techne | Catalog # 7554

Citations (1)

COA / SDS

Potent coronavirus helicase inhibitor; also inhibits human papillomavirus E6

Key Product Details

Description:	Potent coronavirus helicase inhibitor; also inhibits human papillomavirus E6
Chemical Name:	2,4-Dihydro-5-[[(2-nitrophenyl)thio]methyl]-4-(2-propen-1-yl)-3H-1,2,4-triazole-3-thione
Purity:	≥98% (HPLC)
Molecular Weight:	308.37

View Full Technical Details for SSYA10-001

Technical Data
Citations

Biological Activity for SSYA10-001

SSYA10-001 is a potent coronavirus helicase inhibitor (IC₅₀ values are 0.046 μM and >3 μM for unwinding and ATPase, respectively). Inhibits SARS-CoV-2 Nsp13 helicase (IC₅₀ = 3.5 μM), blocks dsDNA and dsRNA unwinding activities of Nsp13 (IC₅₀ values are 5.3 μM and 5.7 μM respectively). In a SARS-CoV replicon assay SSYA10-001 inhibits (+) sense but not (-) sense RNA synthesis (EC₅₀ = 8.95 μM). Also inhibits human papillomavirus E6 (IC₅₀ = 10 μM)

Technical Data for SSYA10-001

M. Wt	308.37
Formula	C₁₂H₁₂N₄O₂S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	675104-49-1
PubChem ID	2807230
InChi Key	VWFIHGWHMXSTAO-UHFFFAOYSA-N
Smiles	C=CCN1C(NN=C1CSC2=C(N(=O)=O)C=CC=C2)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SSYA10-001

References are publications that support the biological activity of the product.

Nizi Discovery of 2-phenylquinolines with broad-spectrum anti-coronavirus activity. ACS Med.Chem.Lett. 2022 PMID: 35571875
Spratt Coronavirus helicases: attractive and unique targets of antiviral drug-development and therapeutic patents. Expert Opin.Ther.Pat. 2021 PMID: 33593200
Malecka Identification and characterization of small molecule human papillomavirus E6 inhibitors. ACS Chem.Biol. 2014 PMID: 24854633
Kumar and Lupoli Exploiting existing molecular scaffolds for long-term COVID treatment. ACS Med.Chem.Lett. 2020 PMID: 32665808
Adedeji Severe acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic acid unwinding of the viral helicase. Antimicrob.Agents Chemother. 2012 PMID: 22733076

SSYA10-001

Tocris Bioscience, part of Bio-Techne | Catalog # 7554

Key Product Details

Biological Activity for SSYA10-001

Technical Data for SSYA10-001

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for SSYA10-001

Product Documents for SSYA10-001

COA

Certificate of Analysis

SDS

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