STAD 2

Name: STAD 2
Brand: Tocris Bioscience
SKU: 6566

Tocris Bioscience, part of Bio-Techne | Catalog # 6566

COA / SDS

AKAP disruptor; selectively binds PKA-RII and blocks its interaction with AKAP; cell permeable

Discontinued Product

6566 has been discontinued. View all AKAP Inhibitors products.

Key Product Details

Description:	AKAP disruptor; selectively binds PKA-RII and blocks its interaction with AKAP; cell permeable
Molecular Weight:	2096.68

View Full Technical Details for STAD 2

Technical Data
Citations

Biological Activity for STAD 2

STAD 2 is an AKAP disruptor. Selectively binds PKA-RII subunit with high affinity (K_d = 6.2 nM) and blocks its interaction with AKAP. Cell permeable. Selectively permeable to malaria-infected red blood cells and displays antimalarial activity through a PKA-independent mechanism.

Technical Data for STAD 2

M. Wt	2096.68
Formula	C₁₀₂H₁₈₂N₂₄O₂₂
Single Letter Sequence	KKLAKFLVSXALKXALK (Modifications: Lys-1 = NH2-PEG3-CH2-CO-Lys, X = (S)-2-(4-pentenyl)alanine, X-10 and X-14 stapled together with a double bond)
Storage	Store at -20°C
CAS Number	1542100-77-5
Smiles	CC(C[C@@H](C(N[C@H](C(N)=O)CCCCN)=O)NC([C@@H](NC([C@@]1(CCC/C=C/CCC[C@](NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(COCCOCCOCCN)=O)CCCCN)=O)CCCCN)=O)CC(C)C)=O)C)=O)CCCCN)=O)CC2=CC=CC=C2)=O)CC(C)C)=O)=O)CO)=O)(C(N[C@H](C(N[C@H](C(N[C@H](C(N1)=O)CCCCN)=O)CC(C)C)=O)C)=O)C)C)=O)C)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for STAD 2

References are publications that support the biological activity of the product.

Flaherty The stapled AKAP disruptor peptide STAD-2 displays antimalarial activity through a PKA-independent mechanism. PLoS One 2015 PMID: 26010880
Wang Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides. ACS Chem.Biol. 2014 PMID: 24422448
Bendzunas Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2. Bioorg.Med.Chem. 2018 PMID: 29449124

STAD 2

Tocris Bioscience, part of Bio-Techne | Catalog # 6566

Key Product Details

Biological Activity for STAD 2

Technical Data for STAD 2

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for STAD 2

Product Documents for STAD 2

COA

Certificate of Analysis

SDS

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