STF 083010

Name: STF 083010
Brand: Tocris Bioscience
SKU: 4509

Tocris Bioscience, part of Bio-Techne | Catalog # 4509

Citations (15)

COA / SDS

Inhibits IRE1α endonuclease activity

Key Product Details

Description:	Inhibits IRE1α endonuclease activity
Chemical Name:	N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	317.38

View Full Technical Details for STF 083010

Technical Data
Citations

Biological Activity for STF 083010

STF 083010 is a inhibitor of IRE1α endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138⁺ multiple myeloma (MM) cells in vitro; inhibits bortezomib-induced XBP1 activity in myeloma xenografts in vivo. Does not alter IRE1α kinase activity.

Technical Data for STF 083010

M. Wt	317.38
Formula	C₁₅H₁₁NO₃S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	307543-71-1
PubChem ID	11487816
InChi Key	RAKGNVNONBJBSW-UHFFFAOYSA-N
Smiles	OC1=CC=C(C=CC=C2)C2=C1/C=N/S(C3=CC=CS3)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for STF 083010

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.74	100

Preparing Stock Solutions for STF 083010

The following data is based on the product molecular weight 317.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.15 mL	15.75 mL	31.51 mL
5 mM	0.63 mL	3.15 mL	6.30 mL
10 mM	0.32 mL	1.58 mL	3.15 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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References for STF 083010

References are publications that support the biological activity of the product.

Kraskiewicz and FitzGerald InterfERing with endoplasmic reticulum stress. Trends Pharmacol.Sci. 2012 PMID: 22112465
Papandreou Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood. 2011 PMID: 21081713