STF 31

Tocris Bioscience, part of Bio-Techne | Catalog # 4484

(1)

Citations (14)

COA / SDS

NAMPT inhibitor; also GLUT1 inhibitor

Key Product Details

Description:	NAMPT inhibitor; also GLUT1 inhibitor
Chemical Name:	4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinylbenzamide
Purity:	≥99% (HPLC)
Molecular Weight:	423.53

View Full Technical Details for STF 31

Technical Data
Citations / Reviews (1)

Biological Activity for STF 31

STF 31 is an inhibitor of GLUT1; inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells. Activity causes necrotic cell death in von Hippel-Lindau (VHL)-deficient RCC cells. Also NAMPT inhibitor. Eliminates human pluripotent stem cells from culture with limited toxicity towards differentiated cells.

Compound Libraries for STF 31

STF 31 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for STF 31

M. Wt	423.53
Formula	C₂₃H₂₅N₃O₃S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	724741-75-7
PubChem ID	984333
InChi Key	NGQPRVWTFNBUHA-UHFFFAOYSA-N
Smiles	O=C(NC2=CN=CC=C2)C1=CC=C(CNS(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for STF 31

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.35	100

Preparing Stock Solutions for STF 31

The following data is based on the product molecular weight 423.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.36 mL	11.81 mL	23.61 mL
5 mM	0.47 mL	2.36 mL	4.72 mL
10 mM	0.24 mL	1.18 mL	2.36 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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Reconstitution Calculator

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References for STF 31

References are publications that support the biological activity of the product.

Adams NAMPT is the cellular target of STF-31-like small-molecule probes. ACS Chem.Biol. 2014 PMID: 25058389
Kropp Inhibition of an NAD⁺ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells. Stem Cells Transl.Med. 2015 PMID: 25834119
Chan Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci.Transl.Med. 2011 PMID: 21813754