SU 6668

Tocris Bioscience, part of Bio-Techne | Catalog # 3335

COA / SDS

PDGFR, VEGFR and FGFR inhibitor

Key Product Details

Description:	PDGFR, VEGFR and FGFR inhibitor
Alternative Names:	TSU68,Orantinib
Chemical Name:	5-[1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	310.35

View Full Technical Details for SU 6668

Technical Data
Citations

Biological Activity for SU 6668

SU 6668 is an ATP-competitive PDGFR, VEGF and FGFR inhibitor (IC₅₀ values are 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively). Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC₅₀ values are 0.41, 9.3 and 16.5 μM for VEGF, FGF and PDGF-stimulated growth respectively) and induces > 75% growth inhibition against a broad range of tumor types in vivo. Exhibits antiangiogenic, anti-inflammatory, antimetastatic and proapoptotic activity and is orally active.

Technical Data for SU 6668

M. Wt	310.35
Formula	C₁₈H₁₈N₂O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	252916-29-3
PubChem ID	5329099
InChi Key	NHFDRBXTEDBWCZ-ZROIWOOFSA-N
Smiles	O=C2NC1=CC=CC=C1/C2=C/C3=C(C)C(CCC(O)=O)=C(C)N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SU 6668

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH	31.03	100
	DMSO	31.03	100

Preparing Stock Solutions for SU 6668

The following data is based on the product molecular weight 310.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.22 mL	16.11 mL	32.22 mL
5 mM	0.64 mL	3.22 mL	6.44 mL
10 mM	0.32 mL	1.61 mL	3.22 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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References for SU 6668

References are publications that support the biological activity of the product.

Laird SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. Cancer Res. 2000 PMID: 10945623
Yamamoto TSU68 prevents liver metastasis of colon cancer xenografts by modulating the premetastatic niche. Cancer Res. 2008 PMID: 19047154
Sun Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J.Med.Chem. 1999 PMID: 10602697