T 0156 hydrochloride

Name: T 0156 hydrochloride
Brand: Tocris Bioscience
SKU: 1676

Tocris Bioscience, part of Bio-Techne | Catalog # 1676

COA / SDS

Highly potent, selective PDE5 inhibitor

Discontinued Product

1676 has been discontinued. View all Phosphodiesterase Inhibitors products.

Key Product Details

Description:	Highly potent, selective PDE5 inhibitor
Chemical Name:	1,2-Dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	620.06

View Full Technical Details for T 0156 hydrochloride

Technical Data
Citations

Biological Activity for T 0156 hydrochloride

T 0156 hydrochloride is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5); more selective than sildenafil (IC₅₀ values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). Selective over 30 other enzymes and receptors (IC₅₀ > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum. Active in vivo.

Licensing Information

Sold with the permission of Tanabe Seiyaku Co. Ltd.

Technical Data for T 0156 hydrochloride

M. Wt	620.06
Formula	C₃₁H₂₉N₅O₇.HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	324572-93-2
PubChem ID	9852041
InChi Key	RBJCBXAXUHCWBR-UHFFFAOYSA-N
Smiles	Cl.COC(=O)C1=C(C2=CC(OC)=C(OC)C(OC)=C2)C2=CC=NC(OCC3=NC=CC=N3)=C2C(=O)N1CC1=CC=NC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for T 0156 hydrochloride

References are publications that support the biological activity of the product.

Mochida T-0156, a novel phosphodiesterase type 5 inhibitor, and silde. have different pharmacological effects on penile tumescence and electroretinogram in dogs. Eur.J.Pharmacol. 2004 PMID: 14757152
Mochida Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor. Eur.J.Pharmacol. 2002 PMID: 12450574