Targapremir 210

Name: Targapremir 210
Brand: Tocris Bioscience
SKU: 6586

Tocris Bioscience, part of Bio-Techne | Catalog # 6586

Citations (2)

COA / SDS

Inhibits formation of miR-210

Key Product Details

Description:	Inhibits formation of miR-210
Chemical Name:	N-(3-Azidopropyl)-4-[3-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]phenoxy]butanamide
Purity:	≥98% (HPLC)
Molecular Weight:	592.71

View Full Technical Details for Targapremir 210

Technical Data
Citations

Biological Activity for Targapremir 210

Targapremir 210 inhibits formation of mature miR-210 (IC₅₀ = 200 nM) by binding to Dicer binding site of the miR-210 hairpin precursor (K_d = 200 nM) and inhibits Dicer processing of the miRNA. Decreases levels of miR-210 and HIF-1α mRNA, and induces apoptosis in MDA-MB-231 cells cultured under hypoxic conditions. Reduces tumor expression of HIF-1α mRNA and miR-210, and tumor growth in a triple negative breast cancer mouse model.

Technical Data for Targapremir 210

M. Wt	592.71
Formula	C₃₂H₃₆N₁₀O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1049722-30-6
PubChem ID	44221088
InChi Key	PAYVJEWMAWLKAP-UHFFFAOYSA-N
Smiles	CN1CCN(C2=CC=C3N=C(C4=CC=C5N=C(C6=CC(OCCCC(NCCCN=[N+]=[N-])=O)=CC=C6)NC5=C4)NC3=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Targapremir 210

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	59.27	100
	ethanol	59.27	100

Preparing Stock Solutions for Targapremir 210

The following data is based on the product molecular weight 592.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.69 mL	8.44 mL	16.87 mL
5 mM	0.34 mL	1.69 mL	3.37 mL
10 mM	0.17 mL	0.84 mL	1.69 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

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References for Targapremir 210

References are publications that support the biological activity of the product.

Childs-Disney Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive. ACS.Chem.Biol 2012 PMID: 22332923
Costales Small molecule inhibition of microRNA-210 reprograms an oncogenic hypoxic circuit. J.Am.Chem.Soc. 2017 PMID: 28240549