TBCA

Name: TBCA
Brand: Tocris Bioscience
SKU: 2825

Tocris Bioscience, part of Bio-Techne | Catalog # 2825

Citations (7)

COA / SDS

Selective CK2 inhibitor

Key Product Details

Description:	Selective CK2 inhibitor
Chemical Name:	(2E)-3-(2,3,4,5-Tetrabromophenyl)-2-propenoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	463.74

View Full Technical Details for TBCA

Technical Data
Citations

Biological Activity for TBCA

TBCA is a selective CK2 inhibitor (IC₅₀ = 110 nM). Exhibits selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases. Reduces viability of Jurkat cells in vitro.

Technical Data for TBCA

M. Wt	463.74
Formula	C₉H₄Br₄O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	934358-00-6
PubChem ID	16760346
InChi Key	SVJQCVOKYJWUBC-OWOJBTEDSA-N
Smiles	BrC1=C(/C=C/C(O)=O)C=C(Br)C(Br)=C1Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TBCA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.37	100

Preparing Stock Solutions for TBCA

The following data is based on the product molecular weight 463.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.16 mL	10.78 mL	21.56 mL
5 mM	0.43 mL	2.16 mL	4.31 mL
10 mM	0.22 mL	1.08 mL	2.16 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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Reconstitution Calculator

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References for TBCA

References are publications that support the biological activity of the product.

Pagano Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors. Chembiochem. 2007 PMID: 17133643