TC-DAPK 6

Name: TC-DAPK 6
Brand: Tocris Bioscience
SKU: 4301

Tocris Bioscience, part of Bio-Techne | Catalog # 4301

Citations (2)

COA / SDS

Potent and selective inhibitor of DAPK1

Key Product Details

Description:	Potent and selective inhibitor of DAPK1
Chemical Name:	(4Z)-2-[(E)-2-Phenylethenyl)-4-(3-pyridinylmethylene)-5(4H)-oxazolone
Purity:	≥98% (HPLC)
Molecular Weight:	276.29

View Full Technical Details for TC-DAPK 6

Technical Data
Citations

Biological Activity for TC-DAPK 6

TC-DAPK 6 is a potent and selective, ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) (IC₅₀ values are 69 and 225 nM for DAPK1 and DAPK3 respectively, when assayed with 10 μM ATP). Displays selectivity for DAPK1 over a range of 48 other kinases, including Abl, AMPK, Chk1, Met and Src (IC₅₀ > 10 μM).

Compound Libraries for TC-DAPK 6

TC-DAPK 6 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for TC-DAPK 6

M. Wt	276.29
Formula	C₁₇H₁₂N₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	2439180-90-0
PubChem ID	2360773
InChi Key	GFGMISOSPOPSHN-NOCYUORASA-N
Smiles	O=C1OC(/C=C/C3=CC=CC=C3)=N\C1=C/C2=CC=CN=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-DAPK 6

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	13.81	50

Preparing Stock Solutions for TC-DAPK 6

The following data is based on the product molecular weight 276.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	7.24 mL	36.19 mL	72.39 mL
2.5 mM	1.45 mL	7.24 mL	14.48 mL
5 mM	0.72 mL	3.62 mL	7.24 mL
25 mM	0.14 mL	0.72 mL	1.45 mL

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References for TC-DAPK 6

References are publications that support the biological activity of the product.

Okamoto Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J.Med.Chem. 2009 PMID: 19877644