TC-I 2014

Name: TC-I 2014
Brand: Tocris Bioscience
SKU: 5410

Tocris Bioscience, part of Bio-Techne | Catalog # 5410

Citations (2)

COA / SDS

Potent TRPM8 antagonist

Key Product Details

Description:	Potent TRPM8 antagonist
Chemical Name:	3-[7-(Trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene
Purity:	≥98% (HPLC)
Molecular Weight:	467.41

View Full Technical Details for TC-I 2014

Technical Data
Citations

Biological Activity for TC-I 2014

TC-I 2014 is a potent TRPM8 antagonist (IC₅₀ values are 0.8, 3.0 and 4.4 nM for canine, human and rat channels respectively). Exhibits antiallodynic properties in pain models in vivo.

Compound Libraries for TC-I 2014

TC-I 2014 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TC-I 2014

M. Wt	467.41
Formula	C₂₃H₁₉F₆N₃O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1221349-53-6
PubChem ID	45274257
InChi Key	GZINXHRSQAMEQY-ZZEZOPTASA-N
Smiles	FC(C(C=CC=C3)=C3C1=CC(C(F)(F)F)=C(NC(C4=NOC5(CCCCC5)C4)=N2)C2=C1)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-I 2014

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	46.74	100
	ethanol	46.74	100

Preparing Stock Solutions for TC-I 2014

The following data is based on the product molecular weight 467.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.14 mL	10.70 mL	21.39 mL
5 mM	0.43 mL	2.14 mL	4.28 mL
10 mM	0.21 mL	1.07 mL	2.14 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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References for TC-I 2014

References are publications that support the biological activity of the product.

Parks Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J.Med.Chem. 2011 PMID: 21128593