TC-MCH 7c

Name: TC-MCH 7c
Brand: Tocris Bioscience
SKU: 4365

Tocris Bioscience, part of Bio-Techne | Catalog # 4365

Citations (5)

COA / SDS

Selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist

Key Product Details

Description:	Selective melanin-concentrating hormone receptor 1 (MCH₁R) antagonist
Chemical Name:	4-[(4-Fluorophenyl)methoxy]-1-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2(1H)-pyridinone
Purity:	≥97% (HPLC)
Molecular Weight:	408.47

View Full Technical Details for TC-MCH 7c

Technical Data
Citations

Biological Activity for TC-MCH 7c

TC-MCH 7c is a potent, selective melanin-concentrating hormone receptor 1 (MCH₁R) antagonist (IC₅₀= 5.6 nM in hMCH₁R-expressing CHO cells). Displays selectivity for MCH₁R over MCH₂R (IC₅₀ = > 10 μM). Decreases body weight in a mouse model of diet-induced obesity. Brain penetrant; orally active.

Technical Data for TC-MCH 7c

M. Wt	408.47
Formula	C₂₄H₂₅FN₂O₃
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	864756-35-4
PubChem ID	11654412
InChi Key	ANCFKYJMXNMYNZ-UHFFFAOYSA-N
Smiles	O=C1C=C(OCC3=CC=C(F)C=C3)C=CN1C2=CC=C(OCCN4CCCC4)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-MCH 7c

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	40.85	100
	DMSO	20.42	50

Preparing Stock Solutions for TC-MCH 7c

The following data is based on the product molecular weight 408.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.45 mL	12.24 mL	24.48 mL
5 mM	0.49 mL	2.45 mL	4.90 mL
10 mM	0.24 mL	1.22 mL	2.45 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for TC-MCH 7c

References are publications that support the biological activity of the product.

Ito Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice. Eur.J.Pharmacol. 2009 PMID: 19836369
Haga Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists. Bioorg.Med.Chem. 2011 PMID: 21190859