TCS 2002

Name: TCS 2002
Brand: Tocris Bioscience
SKU: 3869

Tocris Bioscience, part of Bio-Techne | Catalog # 3869

Citations (5)

COA / SDS

Potent GSK-3β inhibitor

Key Product Details

Chemical Name:	2-Methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]-1,3,4-oxadiazole
Purity:	≥99%
Molecular Weight:	338.38 kDa

View Full Technical Details for TCS 2002

Technical Data
Citations

Biological Activity for TCS 2002

TCS 2002 is a potent inhibitor of GSK-3β (IC₅₀ = 35 nM). Oral adminstration inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain.

Technical Data for TCS 2002

M. Wt	338.38 kDa
Formula	C₁₈H₁₄N₂O₃S
Storage	Store at +4°C
Purity	≥99%
CAS Number	1005201-24-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TCS 2002

Solubility

Soluble Soluble to 100 mM in DMSO and to 25 mM in ethanol

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for TCS 2002

References are publications that support the biological activity of the product.

Saitoh et al. 2-{3-[4-(alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β with good brain permeability. J.Med.Chem., 2009;52:6270 PMID: 19775160