TCS 359

Tocris Bioscience, part of Bio-Techne | Catalog # 2591

COA / SDS

Potent FLT3 inhibitor

Key Product Details

Chemical Name:	2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-benzo[b]thiophene-3-carboxamide
Purity:	≥99%
Molecular Weight:	360.43 kDa

View Full Technical Details for TCS 359

Technical Data
Citations

Biological Activity for TCS 359

TCS 359 is a potent inhibitor of FLT3 receptor tyrosine kinase (IC₅₀ = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC₅₀ = 340 nM).

Technical Data for TCS 359

M. Wt	360.43 kDa
Formula	C₁₈H₂₀N₂O₄S
Storage	Store at +4°C
Purity	≥99%
CAS Number	301305-73-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TCS 359

Solubility

Soluble Soluble to 30 mM in DMSO

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References for TCS 359

References are publications that support the biological activity of the product.

Patch et al. Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg.Med.Chem.Lett., 2006;16:3282 PMID: 16580199